LymphedemaV1, Main, Exploration, bibRecord, 000542

Foxc2 influences alveolar epithelial cell differentiation during lung development.

Identifieur interne : 000542 ( Main/Exploration ); précédent : 000541; suivant : 000543

Foxc2 influences alveolar epithelial cell differentiation during lung development.

Auteurs : Mayoko Tsuji [Japon] ; Masae Morishima [Japon] ; Kazuhiko Shimizu [Japon] ; Shunichi Morikawa [Japon] ; Mikael Heglind [Suède] ; Sven Enerb Ck [Suède] ; Taichi Ezaki [Japon] ; Jun Tamaoki [Japon]

Source :

Development, growth & differentiation [ 1440-169X ] ; 2017.

RBID : pubmed:28675425

Abstract

FOXC2, a forkhead transcriptional factor, is a candidate gene for congenital heart diseases and lymphedema-distichiasis syndrome and yellow nail syndrome; however, there are no reports on Foxc2 and the development of the lung. We have identified lung abnormalities in Foxc2-knockout embryos during investigation of cardiac development. The aim of this study was to clarify the morphological characteristics during lung development using ICR-Foxc2 knockout lungs. Mutant fetuses at embryonic days 10.5-18.5 were obtained from mating of Foxc2(+/-) mice and then analyzed. Notably, Foxc2-knockout lungs appeared parenchymatous and much smaller than those of the wild-type littermates. In the Foxc2 knockout lungs, the capillary beds remained distant from the alveolar epithelium until the late stages, the number of type2 alveolar cells per alveolar progenitor cell was lower and the type1 alveolar cells were thicker in Foxc2 knockout mice. In contrast, Foxc2 expression was only detected in the mesenchyme of the lung buds at E10.5, and it disappeared at E11.5 in Foxc2-LacZ knockin mice. Furthermore, the expression of Lef1 was significantly inhibited in E11.5 lungs. All of these results suggest that the abnormalities in Foxc2 knockout mice may involve maldifferentiation of alveolar epithelial cells and capillary vessel endothelial-alveolar epithelial approach as well as lymph vessel malformation. This is the first report about relationship between Foxc2 and lung development. This animal model might provide an important clue for elucidating the mechanism of lung development and the cause of respiratory diseases.

DOI: 10.1111/dgd.12368
PubMed: 28675425

Affiliations:

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Foxc2 influences alveolar epithelial cell differentiation during lung development.</title>
<author><name sortKey="Tsuji, Mayoko" sort="Tsuji, Mayoko" uniqKey="Tsuji M" first="Mayoko" last="Tsuji">Mayoko Tsuji</name>
<affiliation wicri:level="3"><nlm:affiliation>First Department of Medicine, Tokyo Women's Medical University, Tokyo, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>First Department of Medicine, Tokyo Women's Medical University, Tokyo</wicri:regionArea>
<placeName><settlement type="city">Tokyo</settlement>
<region type="région">Région de Kantō</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Morishima, Masae" sort="Morishima, Masae" uniqKey="Morishima M" first="Masae" last="Morishima">Masae Morishima</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Anatomy and Developmental Biology, Tokyo Women's Medical University, Tokyo, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Anatomy and Developmental Biology, Tokyo Women's Medical University, Tokyo</wicri:regionArea>
<placeName><settlement type="city">Tokyo</settlement>
<region type="région">Région de Kantō</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Shimizu, Kazuhiko" sort="Shimizu, Kazuhiko" uniqKey="Shimizu K" first="Kazuhiko" last="Shimizu">Kazuhiko Shimizu</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Anatomy and Developmental Biology, Tokyo Women's Medical University, Tokyo, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Anatomy and Developmental Biology, Tokyo Women's Medical University, Tokyo</wicri:regionArea>
<placeName><settlement type="city">Tokyo</settlement>
<region type="région">Région de Kantō</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Morikawa, Shunichi" sort="Morikawa, Shunichi" uniqKey="Morikawa S" first="Shunichi" last="Morikawa">Shunichi Morikawa</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Anatomy and Developmental Biology, Tokyo Women's Medical University, Tokyo, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Anatomy and Developmental Biology, Tokyo Women's Medical University, Tokyo</wicri:regionArea>
<placeName><settlement type="city">Tokyo</settlement>
<region type="région">Région de Kantō</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Heglind, Mikael" sort="Heglind, Mikael" uniqKey="Heglind M" first="Mikael" last="Heglind">Mikael Heglind</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Medical Biochemistry and Cell Biology, Institute of Biomedicine, University of Gothenburg, Gothenburg, Sweden.</nlm:affiliation>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Medical Biochemistry and Cell Biology, Institute of Biomedicine, University of Gothenburg, Gothenburg</wicri:regionArea>
<wicri:noRegion>Gothenburg</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Enerb Ck, Sven" sort="Enerb Ck, Sven" uniqKey="Enerb Ck S" first="Sven" last="Enerb Ck">Sven Enerb Ck</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Medical Biochemistry and Cell Biology, Institute of Biomedicine, University of Gothenburg, Gothenburg, Sweden.</nlm:affiliation>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Medical Biochemistry and Cell Biology, Institute of Biomedicine, University of Gothenburg, Gothenburg</wicri:regionArea>
<wicri:noRegion>Gothenburg</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ezaki, Taichi" sort="Ezaki, Taichi" uniqKey="Ezaki T" first="Taichi" last="Ezaki">Taichi Ezaki</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Anatomy and Developmental Biology, Tokyo Women's Medical University, Tokyo, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Anatomy and Developmental Biology, Tokyo Women's Medical University, Tokyo</wicri:regionArea>
<placeName><settlement type="city">Tokyo</settlement>
<region type="région">Région de Kantō</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tamaoki, Jun" sort="Tamaoki, Jun" uniqKey="Tamaoki J" first="Jun" last="Tamaoki">Jun Tamaoki</name>
<affiliation wicri:level="3"><nlm:affiliation>First Department of Medicine, Tokyo Women's Medical University, Tokyo, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>First Department of Medicine, Tokyo Women's Medical University, Tokyo</wicri:regionArea>
<placeName><settlement type="city">Tokyo</settlement>
<region type="région">Région de Kantō</region>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2017">2017</date>
<idno type="RBID">pubmed:28675425</idno>
<idno type="pmid">28675425</idno>
<idno type="doi">10.1111/dgd.12368</idno>
<idno type="wicri:Area/PubMed/Corpus">000120</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000120</idno>
<idno type="wicri:Area/PubMed/Curation">000120</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000120</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000120</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000120</idno>
<idno type="wicri:Area/Ncbi/Merge">009242</idno>
<idno type="wicri:Area/Ncbi/Curation">009242</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">009242</idno>
<idno type="wicri:Area/Main/Merge">000542</idno>
<idno type="wicri:Area/Main/Curation">000542</idno>
<idno type="wicri:Area/Main/Exploration">000542</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Foxc2 influences alveolar epithelial cell differentiation during lung development.</title>
<author><name sortKey="Tsuji, Mayoko" sort="Tsuji, Mayoko" uniqKey="Tsuji M" first="Mayoko" last="Tsuji">Mayoko Tsuji</name>
<affiliation wicri:level="3"><nlm:affiliation>First Department of Medicine, Tokyo Women's Medical University, Tokyo, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>First Department of Medicine, Tokyo Women's Medical University, Tokyo</wicri:regionArea>
<placeName><settlement type="city">Tokyo</settlement>
<region type="région">Région de Kantō</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Morishima, Masae" sort="Morishima, Masae" uniqKey="Morishima M" first="Masae" last="Morishima">Masae Morishima</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Anatomy and Developmental Biology, Tokyo Women's Medical University, Tokyo, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Anatomy and Developmental Biology, Tokyo Women's Medical University, Tokyo</wicri:regionArea>
<placeName><settlement type="city">Tokyo</settlement>
<region type="région">Région de Kantō</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Shimizu, Kazuhiko" sort="Shimizu, Kazuhiko" uniqKey="Shimizu K" first="Kazuhiko" last="Shimizu">Kazuhiko Shimizu</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Anatomy and Developmental Biology, Tokyo Women's Medical University, Tokyo, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Anatomy and Developmental Biology, Tokyo Women's Medical University, Tokyo</wicri:regionArea>
<placeName><settlement type="city">Tokyo</settlement>
<region type="région">Région de Kantō</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Morikawa, Shunichi" sort="Morikawa, Shunichi" uniqKey="Morikawa S" first="Shunichi" last="Morikawa">Shunichi Morikawa</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Anatomy and Developmental Biology, Tokyo Women's Medical University, Tokyo, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Anatomy and Developmental Biology, Tokyo Women's Medical University, Tokyo</wicri:regionArea>
<placeName><settlement type="city">Tokyo</settlement>
<region type="région">Région de Kantō</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Heglind, Mikael" sort="Heglind, Mikael" uniqKey="Heglind M" first="Mikael" last="Heglind">Mikael Heglind</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Medical Biochemistry and Cell Biology, Institute of Biomedicine, University of Gothenburg, Gothenburg, Sweden.</nlm:affiliation>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Medical Biochemistry and Cell Biology, Institute of Biomedicine, University of Gothenburg, Gothenburg</wicri:regionArea>
<wicri:noRegion>Gothenburg</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Enerb Ck, Sven" sort="Enerb Ck, Sven" uniqKey="Enerb Ck S" first="Sven" last="Enerb Ck">Sven Enerb Ck</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Medical Biochemistry and Cell Biology, Institute of Biomedicine, University of Gothenburg, Gothenburg, Sweden.</nlm:affiliation>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Medical Biochemistry and Cell Biology, Institute of Biomedicine, University of Gothenburg, Gothenburg</wicri:regionArea>
<wicri:noRegion>Gothenburg</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ezaki, Taichi" sort="Ezaki, Taichi" uniqKey="Ezaki T" first="Taichi" last="Ezaki">Taichi Ezaki</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Anatomy and Developmental Biology, Tokyo Women's Medical University, Tokyo, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Anatomy and Developmental Biology, Tokyo Women's Medical University, Tokyo</wicri:regionArea>
<placeName><settlement type="city">Tokyo</settlement>
<region type="région">Région de Kantō</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tamaoki, Jun" sort="Tamaoki, Jun" uniqKey="Tamaoki J" first="Jun" last="Tamaoki">Jun Tamaoki</name>
<affiliation wicri:level="3"><nlm:affiliation>First Department of Medicine, Tokyo Women's Medical University, Tokyo, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>First Department of Medicine, Tokyo Women's Medical University, Tokyo</wicri:regionArea>
<placeName><settlement type="city">Tokyo</settlement>
<region type="région">Région de Kantō</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">Development, growth & differentiation</title>
<idno type="eISSN">1440-169X</idno>
<imprint><date when="2017" type="published">2017</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">FOXC2, a forkhead transcriptional factor, is a candidate gene for congenital heart diseases and lymphedema-distichiasis syndrome and yellow nail syndrome; however, there are no reports on Foxc2 and the development of the lung. We have identified lung abnormalities in Foxc2-knockout embryos during investigation of cardiac development. The aim of this study was to clarify the morphological characteristics during lung development using ICR-Foxc2 knockout lungs. Mutant fetuses at embryonic days 10.5-18.5 were obtained from mating of Foxc2(+/-) mice and then analyzed. Notably, Foxc2-knockout lungs appeared parenchymatous and much smaller than those of the wild-type littermates. In the Foxc2 knockout lungs, the capillary beds remained distant from the alveolar epithelium until the late stages, the number of type2 alveolar cells per alveolar progenitor cell was lower and the type1 alveolar cells were thicker in Foxc2 knockout mice. In contrast, Foxc2 expression was only detected in the mesenchyme of the lung buds at E10.5, and it disappeared at E11.5 in Foxc2-LacZ knockin mice. Furthermore, the expression of Lef1 was significantly inhibited in E11.5 lungs. All of these results suggest that the abnormalities in Foxc2 knockout mice may involve maldifferentiation of alveolar epithelial cells and capillary vessel endothelial-alveolar epithelial approach as well as lymph vessel malformation. This is the first report about relationship between Foxc2 and lung development. This animal model might provide an important clue for elucidating the mechanism of lung development and the cause of respiratory diseases.</div>
</front>
</TEI>
<affiliations><list><country><li>Japon</li>
<li>Suède</li>
</country>
<region><li>Région de Kantō</li>
</region>
<settlement><li>Tokyo</li>
</settlement>
</list>
<tree><country name="Japon"><region name="Région de Kantō"><name sortKey="Tsuji, Mayoko" sort="Tsuji, Mayoko" uniqKey="Tsuji M" first="Mayoko" last="Tsuji">Mayoko Tsuji</name>
</region>
<name sortKey="Ezaki, Taichi" sort="Ezaki, Taichi" uniqKey="Ezaki T" first="Taichi" last="Ezaki">Taichi Ezaki</name>
<name sortKey="Morikawa, Shunichi" sort="Morikawa, Shunichi" uniqKey="Morikawa S" first="Shunichi" last="Morikawa">Shunichi Morikawa</name>
<name sortKey="Morishima, Masae" sort="Morishima, Masae" uniqKey="Morishima M" first="Masae" last="Morishima">Masae Morishima</name>
<name sortKey="Shimizu, Kazuhiko" sort="Shimizu, Kazuhiko" uniqKey="Shimizu K" first="Kazuhiko" last="Shimizu">Kazuhiko Shimizu</name>
<name sortKey="Tamaoki, Jun" sort="Tamaoki, Jun" uniqKey="Tamaoki J" first="Jun" last="Tamaoki">Jun Tamaoki</name>
</country>
<country name="Suède"><noRegion><name sortKey="Heglind, Mikael" sort="Heglind, Mikael" uniqKey="Heglind M" first="Mikael" last="Heglind">Mikael Heglind</name>
</noRegion>
<name sortKey="Enerb Ck, Sven" sort="Enerb Ck, Sven" uniqKey="Enerb Ck S" first="Sven" last="Enerb Ck">Sven Enerb Ck</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000542 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000542 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Sante
   |area=    LymphedemaV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     pubmed:28675425
   |texte=   Foxc2 influences alveolar epithelial cell differentiation during lung development.
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:28675425" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a LymphedemaV1

This area was generated with Dilib version V0.6.31.
Data generation: Sat Nov 4 17:40:35 2017. Site generation: Tue Feb 13 16:42:16 2024

Serveur d'exploration sur le lymphœdème

Foxc2 influences alveolar epithelial cell differentiation during lung development.

Foxc2 influences alveolar epithelial cell differentiation during lung development.

Source :

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration sur le lymphœdème
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.